Variables	Model 1 (n = 25972) HR (95% CI)	p	Model 2 (n = 25525) HR (95% CI)	p
Age(years)	1.081 (1.062 - 1.100)	< 0.001	1.073 (1.054 - 1.092)	< 0.001
Female	0.359 (0.227 - 0.567)	< 0.001	0.447 (0.282 - 0.708)	< 0.001
Exercise capacity ≥ 10 METs	0.577 (0.420 - 0.792)	< 0.001	0.684 (0.483 - 0.971)	0.034
Coronary artery calcium score ≥ 400	2.259 (1.438 - 3.549)	< 0.001	3.328 (1.850 - 5.988)	< 0.001
Interaction between CACS & exercise capacity			0.333 (0.128 - 0.866)	0.024
Fasting glucose(mg/dL)			1.009 (1.005 - 1.013)	< 0.001
Serum creatinine (mg/dL)			1.552 (1.144 - 2.107)	0.005
Serum ALT (U/L)			1.007 (1.005 - 1.010)	< 0.001
Serum Albumin (md/dL)			0.324 (0.208 - 0.506)	< 0.001